Protection of ischemic myocardium by Verapamil Yoshiro Nakamura 1 , Jun-ichi Hayashi 1 , Hidezo Mori 1 , Satoshi Ogawa 1 , Masando Takahashi 1 , Shigehiko Hattori 1 , Fumitaka Ohosuzu 1 , Yoshio Tanabe 2 , Kuniko Hara 2 1Cardiopulmonary Division, Department of Internal Medicine, School of Medicine, Keio University 2Eisai Research Labaratories pp.399-403
Published Date 1981/4/15
DOI https://doi.org/10.11477/mf.1404203754
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The protection of the ischemic myocardium following a reduction of left anterior descending blood flow (CBF) with Verapamil was examined in 14 open-chest dogs. CBF and aortic blood flow were measured by electromagnetic flowmeters. In the area which became ischemic by reduction in CBF, myocardial segment length was measured by a pair of small ultrasonic crystals implanted into the endocardial region. Five minutes after reduction of CBF, measurement of hemodynamics and biopsy of the ischemic myocardium for ATP analysis were performed.

In 8 cases of control group, 52.4±3.9% reduction of CBF resulted in a decrease aortic pressure and a reduction of segment shortening. Myocardial ATP content in the ischemic area was 2.963± 0.190μmol/g wet weight. Six cases, of which hemodynamic data were not different from control group's, were medicated by 0.25 mg/kg of Verapamil. Ten to eleven minutes after the injection, CBF was reduced by 57.3±4.1% of preinjection state. None of the hemodynamic data in ischemic state in Verapamil group was different significantly from the data of control group in ischemic state, however, pattern of myocardial shortening in ischemic area was less affected than that of control group. Myocardial ATP content in the ischemic area in Verapamil group was 3.25±0.354 which was significantly higher than that of control group.

Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.


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