発作性上室性頻拍症におけるDisopyramide Phosphateの抗不整脈作用

Antiarrhythmic Actions of Disopyramide Phosphate in Patients with Paroxysmal Supraventricular Tachycardia

　上室性，心室性をとわず発作性頻拍症に対する内科的，外科的治療には様々な試みがなされているが，いまだ充分なものとはいえない。近年，抗不整脈剤としてのDisopyramide Phosphate　（D．P．）の報告が相次いでなされているが^1,2），本邦での報告はきわめて少ない。我々は臨床的に発作性上室頻拍症（PSVT）を疑われた患者に，D．P．を静脈内投与し，その前後に心房ペーシングを用いて，主に電気生理学的変化につき検討し，若干の知見を得たので報告する。

Antiarrhythmic actions of Disopyramide Phos-phate were studied electrophysiologically by using atrial pacing in10 patients (male : 5, famale : 5, average age : 37.1) with clinically suspected paroxysmall supraventricular tachycardia. 4 of 10 patients were pre-excitation syndrome with ano-malous bypass conduction.

After intravenous injection of Disopyramide (1-2 mg/kg), there were not definite changes in blood pressure, heart rate, A-H conduction time, effective refractory period of atrium and AV-node but were signficantly prolonged H-V conduction time (p<0.01) and functional refrac-tory period of AV-node (p<0.005). There were not also definite change in corrected sinus-node recovery time after administration of Disopyr-amide, except 2 patients of case 3 and case 6 with remarkable prolongation, lengthenedfrom 390 msec to 610 msec and from 355 msec to 565 msec. respectively