雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Effects of verapamil and disopyramide phosphate on the termination, reinduction and long-termprevention of paroxysmal supraventricular tachycardia Yukiko Tsuchioka 1 , Hiroshi Nakagawa 1 , Togo Yamagata 1 , Eiichiro Sakura 1 , Masaki Hashimoto 1 , Mitsunori Okamoto 1 , Hideo Matsuura 1 , Goro Kajiyama 1 1The 1st Department of Internal Medicine, Hiroshima University School of Medicine Keyword: 発作性上室性頻拍症(paroxysmal supraventricular tachycardia) , verapamil , disopyramide phosphate pp.243-248
Published Date 1990/3/15
DOI https://doi.org/10.11477/mf.1404900111
  • Abstract
  • Look Inside

The efficacy of verapamil and disopyramide phos-phate for the termination and prevention of paro-xysmal supraventricular tachycardia (PSVT) were studied electrophysiologically in 32 patients, with inducible sustained PSVT (17 patients received vera-pamil, 15 patients received disopyramide). Twelve patients had atrioventricular nodal tachycardia, 7 hadconcealed and 13 had overt Wolff-Parkinson-White syndrome. Intravenous verapamil (0.15mg/kg) temi-nated the sustained PSVT in 15 of the 17 patients (88%) by production of AV block in 13 patients, VA block in one, and a ventricular premature beat in one. PSVT could not be induced in any of these 15 patients after they had received verapamil. In the remaining 2 patients, PSVT could not be terminated by the use of verapamil, but the cycle lengths of PSVT were lengthened. Long-term oral dosages of verapamil of 120-240mg/day were administered in 13 of the 17 patients. All patients except two, whose PSVT was unable to be effected by intravenous verapamil, were well controlled: PSVT disappeared in 7 patients and decreased in 4. Intravenous diso-pyramide (1.5mg/kg) terminated induced PSVT in 10 of the 15 patients (67%) by production of VA block.Although PSVT could not be reinitiated in 5 of these 10 patients, non-sustained PSVT was induced in 2 and sustained PSVT was induced in 3 after having received disopyramide. PSVT was induced in all of the 5 patients who failed to respond to disopyra-mide. The cycle lengths of PSVT after administra-tion of disopyramide remained unchanged. Long-term oral doses of disopyramide (300-600mg/day) was administered in 11 of the 15 patients. 5 patients were well controlled: PSVT disappeared in 4 pati-ents and decreased in one. Oral disopyramide was ineffective in the other 6 patients. In conclusion, we can say that verapamil and disopyramide were useful agents for the management of PSVT. Elect-rophysiological study of patients receiving intrave-nous administration of these agents was necessary for the therapy of PSVT in an outpatient clinic.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

関連文献

もっと見る

文献を共有