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Effects of PaCO2 on inspiratory activity during cough reflex Takashi Nishino 1 , Yoshiyuki Honda 1 1Department of Physiology, School of Medicine, Chiba University pp.173-176
Published Date 1981/2/15
DOI https://doi.org/10.11477/mf.1404203722
  • Abstract
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To assess the relationship of the inspiratory activity during cough reflex to PaCO2 tracheal mucosa was irritated mechanically to elicit cough reflex and the intensity of the inspiratory activity was evaluated from the integrated phrenic nerve activity at three different PaCO2 levels, namely, hypocapnia, normocapnia and hypercapnia. At any level of PaCO2 tracheal irritation produced non-rythmic vigorous inspiratory activity. Max-imal inspiratory activity was not influenced by Paco2 level under all the conditions suggesting that there is a PaCO2-indepent maximal point of the intensity attained by a tidal inspiratory ac-tivity. However, total inspiratory activity during tracheal stimulation was increased as the level of PaCO2 increased. After-effect of the stimulation was significantly longer in normocapnia than in hypocapnia and hypercapnia. These results sug-gest that the intensity of cough reflex and its in-terference to the rythmic respiratory activity are dependent on the central respiratoy state deter-mined by PaCO2.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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