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Hemodynamic Effects of Isoproterenol and Propranolol in Patients with Tetralogy of Fallot accompanied by Repeated Cyanotic Attack Yasuaki Naito 1 , Yasunori Horiguchi 1 , Mamoru Mori 1 , Michiaki Danno 1 , Yoshiyuki Fudemoto 1 , Yasunaru Kawashima 1 , Takeshi Nakada 2 11st Department of Surgery, Osaka University Medical School 2Department of Surgery, Osaka Prefectural Hospital pp.335-339
Published Date 1969/4/15
DOI https://doi.org/10.11477/mf.1404202018
  • Abstract
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The hemodynamic effects of isoproterenol (beta-adrenergic stimulant) and propranolol (beta-adrenergic blockade) were studied on two patients with tetralogy of Fallot, having repeated deep cyanotic attack.

In right ventriculogram all of them had slight degree of right ventricular outflow obstruction, not so narrow pulmonary artery and ventricular septal defect beneath the crista supraventricularis.

By the administration of isoproterenol, the clinical symptoms same with that of cyanoticattack were developed. Then the increase of right to left shunt and degree of right ventricular outflow obstruction, the decrease of pulmonary blood flow and arterial oxygen saturation were observed.

Propranolol evidently released cyanosis and developed the hemodynamic state contrary to the above mentioned effects of isoproterenol. Also this drug was clinically useful in pre-venting and treating cyanotic attack in all of these patients.

These findings and results may suggest that the functional increase of right ventri-cular outflow obstruction is closely related with the mechanism of cyanotic attack in tetralogy of Fallot.


Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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