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The Assessment of Bronchodilator Aerosols on the Airway Obstruction Shin Era 1 , Tomoyuki Tomita 1 , Tetsuro Yokoyama 1 1Department of Internal Medicine, School of Medicine, Keio University pp.975-980
Published Date 1968/11/15
DOI https://doi.org/10.11477/mf.1404201960
  • Abstract
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The present study was conducted to eva-luate the effects of bronchodilator aerosol on the pulmonary physiology. Special interest was taken to compare the response of the parameters representing the degree of airway obstruction.

Thirty-two cases with or without clinical symptoms of airway obstruction were given 2% isoprophenamine aerosols. Prior to and 5 minutes after the aerosol inhalation the pulmonary function studies, including theroutine spirography and the body plethysmo-graphy, were done to collect the informations on the characteristics of the airway dynamics as well as of the lung volumes.

The present data indicated the followings :

1) The spirographic data, obtained prior to and after the bronchodilator aerosol admini-stration, were not sensitive enough to rep-resent the improvement of airway obstruction while the airway resistance or the airway conductance obtained on the body plethysmo-graphy picked up the overmentioned changes in airway dynamics.

2) The specific airway conductance (airway conductance per unit lung volumes) sensiti-vely demonstrated the changes in the dyna-mic properties of the airways even on the subjects accompanied by FEV1.0% within nor-mal limits.

Through the present experimental obser-vation we came to the conclusion that the specific airway conductance obtained by the body plethysmography was the enough sen-sitive and the most physiologically recom-mendable parameter to evaluate the response of the airway dynamics to the bronchodilator administration.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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