Histopathologic Evaluation of Lymphovascular and Venous Invasions in T1 Colorectal Cancers Shinichi Ban 1 1Department of Pathology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan Keyword: 大腸T1癌 , リンパ管侵襲 , 静脈侵襲 , 免疫組織化学 , 弾性線維染色 pp.1083-1091
Published Date 2021/7/25
DOI https://doi.org/10.11477/mf.1403202511
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 Lymphovascular and venous invasions are recognized as subtle changes in the histopathologic examination of T1 colorectal cancers. Therefore, it is a prerequisite to understand the site and histologic findings of the involved vessels and the factors determining the quality and limitation of their detection. Lymphovascular invasion is easily determined when a cancer cell nest is observed in the lumen lined by unequivocal endothelial cells. However, endothelial lining is often indistinct, thereby requiring D2-40 immunohistochemistry for confirmation of the lymphovascular invasion. Venous invasion is generally observed as a cancer cell nest occupying the venous lumen with endothelial impairment, due to which the studies on immunohistochemical endothelial markers are of no use. To clearly determine the veins involved in cancer invasion, it is necessary to incorporate elastic fiber stain that helps in demonstrating the elastic fiber layers of the venous wall around the cancer cell nest. The presence of an accompanying artery provides another marker for venous invasion.

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