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Histological Evaluation of Tumor Budding in Endoscopically Resected T1 Colorectal Cancer Hiroshi Kawachi 1,2 1Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 2Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo Keyword: 大腸癌 , 簇出 , サイトケラチン , 低分化胞巣 pp.1077-1081
Published Date 2021/7/25
DOI https://doi.org/10.11477/mf.1403202509
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 TB(tumor budding)is a single cancer cell or small clusters of four or fewer cancer cells observed histologically at the invasive front of colorectal cancer. TB is evaluated from slides stained with hematoxylin and eosin and graded as Grades 1(BD1), 2(BD2), and 3(BD3)according to the number of TB foci in one field of 20× objective lens. T1 colorectal cancer with BD2 or BD3 is a high-risk tumor for lymph node metastasis. Regarding prominent inflammation or desmoplastic reaction, TB foci are occasionally difficult to identify. Nonetheless, they can be detected by immunohistochemistry using cytokeratin, although the cutoff value of TB requires re-evaluation. In contrast, a cancer cell nest comprising five or more cancer cells without tubular components indicates a PDC(poorly differentiated cluster). Although TB and PDC are mutually independent histological findings, they frequently coexist in the tumor. TB Grade 1(BD1)was recently subclassified into a tumor without TB and a tumor with one to four TB foci, and the former shows an extremely low risk for lymph node metastasis.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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