Stomach and Intestine(Tokyo) Volume 54, Issue 13 (December 2019)
Japanese

Very Early Onset Monogenic Inflammatory Bowel Disease, Report of Two Cases Jun Ishihara 1 , Tatsuki Mizuochi 1 , Tadahiro Yanagi 1 , Yugo Takaki 1 , Shinichiro Yoshioka 2 , Keiichi Mitsuyama 2 1Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan 2Division of Gastroenterology Department of Medicine, Kurume University School of Medicine, Kurume, Japan Keyword: VEO-IBD , very early onset inflammatory bowel disease , monogenic IBD , 遺伝子診断 , IL-10/IL-10受容体欠損症 , Hermansky-Pudlak症候群 pp.1746-1750
Published Date 2019/12/25
DOI https://doi.org/10.11477/mf.1403201908
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 Several studies have reported on monogenic IBD(inflammatory bowel disease)in patients aged <6 years. Here, we present two cases of monogenic IBD:(1)a patient with interleukin-10 receptor deficiency who developed IBD during infancy and achieved remission with hematopoietic stem cell transplantation and(2)another patient with Hermansky-Pudlak syndrome type 1 who developed IBD during infancy and achieved remission with infliximab therapy. Physicians should consider monogenic IBD while treating pediatric patients with IBD aged <6 years.


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基本情報

05362180.54.13.jpg
胃と腸
54巻13号 (2019年12月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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