Endoscopic Diagnosis of Esophageal Neuroendocrine Tumors Taro Iwatsubo 1 , Ryu Ishihara 1 , Masaki Kitamura 2 , Kenshi Matsuno 1 , Hiroyoshi Iwagami 1 , Shuntaro Inoue 1 , Hiroko Nakahira 1 , Noriko Matsuura 1 , Satoki Shichijo 1 , Akira Maekawa 1 , Takashi Kanesaka 1 , Sachiko Yamamoto 1 , Yoji Takeuchi 1 , Koji Higashino 1 , Noriya Uedo 1 , Shinichi Nakatsuka 2 1Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan 2Department of Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan Keyword: 食道内分泌腫瘍 , 食道神経内分泌腫瘍 , 食道神経内分泌細胞癌 , 内視鏡診断 pp.1399-1408
Published Date 2019/9/25
DOI https://doi.org/10.11477/mf.1403201840
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 The Japanese Classification of Esophageal Cancer(11th edition)identified neuroendocrine tumors(NET G1 or G2)and NEC(neuroendocrine carcinoma)as esophageal neuroendocrine tumors. Both diseases rarely occur, particularly the esophageal NET, which is extremely rare among the gastrointestinal NETs ; therefore, reports regarding their endoscopic findings are limited. The characteristics of esophageal NEC are more aggressive than those of the normal types of squamous cell carcinoma. Therefore, several esophageal NECs are diagnosed as advanced cancer and rarely detected as superficial cancer. Preoperative accurate histological diagnosis is required because they have different chemotherapeutic regimens. However, some NECs cannot be accurately histologically diagnosed using biopsy specimens, the gold standard procedure. Therefore, their endoscopic features should be properly understood and, as much as possible, not be overlooked by the pathologist during the histological examination.

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