Eosinophilic Granulomatosis with Polyangiitis Presenting Multiple Ulcerative Lesions in the Small Intestine, Report of a Case Takahide Tanaka 1 , Motohiro Esaki 1 , Atsushi Hirano 1 , Yuta Fuyuno 1 , Shin Fujioka 1 , Yasuharu Okamoto 1 , Junji Umeno 1 , Takahiro Torisu 1 , Tomohiro Moriyama 1 , Yoshifumi Hori 2 , Minako Fujiwara 2 , Takanari Kitazono 1 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Health Science, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan Keyword: 好酸球性多発血管炎性肉芽腫症 , 小腸病変 , カプセル小腸内視鏡 , ダブルバルーン小腸内視鏡 pp.887-892
Published Date 2018/5/25
DOI https://doi.org/10.11477/mf.1403201395
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 A 60-year-old man with a 1-year history of bronchial asthma was referred to our institution owing to lower abdominal pain, diarrhea, and numbness of the upper and lower extremities. While esophagogastroduodenoscopy revealed multiple reddish mucosa and erosions in the jejunum, a biopsy of the jejunal mucosa detected dense eosinophilic infiltration in the submucosa. In addition, capsule endoscopy and double-balloon enteroscopy findings determined multiple erosions and ulcers of variable sizes along with adjoining reddish mucosa throughout the small intestine. Subsequently, the patient was diagnosed with eosinophilic granulomatosis with polyangiitis on the basis of the combination of bronchial asthma, eosinophilia, and multiple mononeuropathy. Accordingly, we initiated therapy with the administration of oral prednisolone(50mg/day)and intravenous cyclophosphamide(500mg/m2), which resulted in significant improvement of the small intestinal lesions.

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