Stomach and Intestine(Tokyo) Volume 54, Issue 3 (March 2019)

Endocytoscopic Observation of the Esophagus:Detailed Methodology and Novel Findings Youichi Kumagai 1 , Kenro Kawada 2 , Kaiyo Takubo 3 , Junko Aida 3 , Kunihiko Amano 1 , Okihide Suzuki 1 , Toru Ishiguro 1 , Shunsuke Muramatsu 1 , Satoshi Hatano 1 , Tetsuya Ito 1 , Noroyasu Chika 1 , Yuu Muta 1 , Azusa Yamamoto 1 , Kei-ichiro Ishibashi 1 , Erito Mochiki 1 , Hideyuki Ishida 1 1Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan 2Department of Esophageal and General Surgery, Tokyo Medical and Dental University, Tokyo 3Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Keyword: endocytoscopy system , 超拡大観察 , 食道癌 , 食道炎 , Barrett食道 pp.374-383
Published Date 2019/3/25
  • Abstract
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 The endocytoscopy system(ECS)is an ultra-high magnification endoscope that allows cell observation in real time in vivo. The latest prototype ECS, GIF-Y0074, is now available on the market. Here, we propose a classification system for the diagnosis of squamous epithelium. This classification is divided into three categories that efficiently differentiate esophageal cancer. An increase in nuclear density and abnormality as well as an enlarged nucleus are distinct features of squamous cell carcinoma(Type 3). In cases exhibiting these features, biopsy histology can be omitted by referring to the ECS findings. Furthermore, in the case of various types of esophagitis(esophagitis after irradiation, gastroesophageal reflux disease, etc.), Barrett's epithelium(goblet cells in the intestinal mucosa and squamous islands), and esophageal cancer, characteristic images that reflect the histological features are obtainable. ECS diagnosis for the esophagus realizes the concept of optical biopsy and enables the omission of biopsy histology.

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54巻3号 (2019年3月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院