The Endoscopic Diagnosis of Gastric Cancers after Successful Helicobacter pylori Eradication Therapy Kazuyoshi Yagi 1 , Chiyumi Oda 1 , Takahiro Hoshi 1 , Shin-ichi Morita 1 , Tsutomu Kanefuji 1 , Takeshi Suda 1 , Shuji Terai 2 1Department of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma, Japan 2Department of Gastroenterology and Hepatology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan Keyword: 胃癌 , 除菌 , 除菌後発見胃癌 , H. pylori , 胃炎様内視鏡像 pp.672-683
Published Date 2018/5/24
DOI https://doi.org/10.11477/mf.1403201363
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 After a successful Helicobacter pylori eradication therapy, gastric cancer is often difficult to diagnose by endoscopy because of its indistinct borderline or the lack of apparent cancer characteristics. We examined the endoscopic findings and histology of patients with gastric cancer who had(eradication group, 24)and had not(non-eradication group, 47)undergone H. pylori eradication therapy. Gastritis-like appearance on conventional endoscopy and NBI-magnifying endoscopy was significantly more frequent in the eradication group. Furthermore, non-neoplastic epithelium appeared to be mixed with cancerous glands in more than 10% of the cancerous areas more frequently in the eradication group. Presumably, gastritis-like finding in the eradication group is because of the appearance of non-neoplastic epithelium mixed with cancerous glands.

 We have previously reported a reversal of red and white coloration in the gastric corpus in some patients after eradication and have referred to it as the "reversal phenomenon on the mucosal borderline"(RP), which is often evident in patients who develop gastric cancer after eradication. Therefore, we conducted a cross-sectional study to evaluate the correlation between RP and gastric cancer after H. pylori eradication therapy. We inferred that gastric cancer appeared more frequently in the RP group than the non-RP group.

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