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要旨●HIV感染者における,下部消化管感染症例の検索のため,2004年8月〜2017年10月までに,377例655件の下部消化管内視鏡検査を施行した.病理組織学的に消化管感染症と診断された症例はCMV(cytomegalovirus)腸炎が61例(16%),アメーバ性大腸炎が18例(5%),腸管スピロヘータ症が9例(2%),HSV腸炎が2例(0.5%),クラミジア腸炎が1例(0.3%),カンジダ症が1例(0.3%),梅毒性直腸炎が1例(0.3%),腸結核が1例(0.3%),ジアルジア症が1例(0.3%),クリプトスポリジウム症が1例(0.3%),サイクロスポーラ症が1例(0.3%)であった.CMV腸炎では,びらん・潰瘍性病変を84%で認め,特徴的とされる打ち抜き潰瘍が50%でみられた.また,他の消化管感染症との合併が多く,28%で認めた.アメーバ性大腸炎は,CMVとの混合感染を48%で起こし,そのうち67%で3cmを超える潰瘍を形成していた.2012年6月〜2017年10月に行った229例392件の下部消化管内視鏡検査で診断された,HIV感染者におけるHPV関連病変は,91例(40%)239病変であった.肉眼形態は,239病変のうち96病変(40%)は平坦型であった.この96病変のうち90病変(94%)が,NBI併用拡大観察で“ドット状血管”,“不均一な分布”,“ネットワーク状血管”を呈し,存在診断に有用であった.
Between August 2004 and October 2017, we reviewed 655 GI(lower gastrointestinal)tract endoscopies in 377 HIV(human immunodeficiency virus)-infected patients to elucidate lower GI lesions in patients with HIV infection. Histopathologically confirmed cases comprised 61 CMV(cytomegalovirus)enterocolitis(16%), 18 amebic colitis(5%), 9 intestinal spirochetosis(2%), 2 herpes simplex virus colitis(0.5%), Chlamydia trachomatis colitis(0.3%), 1 candida infection(0.3%), 1 syphilis of rectum(0.3%), 1 intestinal tuberculosis(0.3%), 1 giardiasis(0.3%), 1 cryptosporidiosis(0.3%), and 1 cyclosporiasis(0.3%). Endoscopic findings of CMV enterocolitis presented 84% of erosions or ulcerative lesions and 50% of punched-out ulcers. Besides, 28% of patients with CMV enterocolitis had other enterocolitic infections. Although amebic colitis occurred in 48% of mixed infections with CMV, 67% patients presented with ulcers with a diameter of >3cm. Between June 2012 and October 2017, we reviewed 392 lower GI tract endoscopies in 229 HIV-infected patients to elucidate HPV(human papillomavirus)-related lesions with HIV infection. Histopathologically confirmed HPV-related lesions cases were 91 patients and 239 lesions. In addition, 96 lesions(40%)of HPV-related lesions were of flat type, and 90 lesions(94%)exhibited dot or irregular distribution or network pattern as visualized by magnification endoscopy with narrowband imaging.
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