Definition and Prevalence of Helicobacter pylori-Negative Gastric Cancer Masanori Ito 1 , Taiji Matsuo 1 , Tomoyuki Boda 1 , Yoko Kitamura 1 , Shiro Oka 2 , Shinji Tanaka 2 , Kazuaki Chayama 1 1Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan 2Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan Keyword: Helicobacter pylori , 感染診断 , 萎縮性胃炎 , 印環細胞癌 pp.835-839
Published Date 2014/5/25
DOI https://doi.org/10.11477/mf.1403114171
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 The prevalence of HpNGC(Helicobacter pylori-negative gastric cancer)is extremely low. The international definition of HpNGC remains controversial ; however, HpNGC shows characteristic pathological and endoscopic features. For example, the absence of atrophic gastritis is typically necessary on histological and endoscopic examination. Signet ring cell carcinoma may be a typical feature of HpNGC. Among patients with gastric cancer, >10% can be sub-classified into group A(increased pepsinogen levels and negativity for Helicobacter pylori antibody)despite the presence of corpus atrophy. The accurate identification of Helicobacter pylori-negative patients is important in clinical practice.

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