Historical Changes in Cases of Gastric Cancer not Associated with Helicobacter pylori Infection, Detected at a Health Checkup Facility Rika Aoki 1 , Mitsugi Yasuda 2 , Akira Yamanoi 3 , Yousuke Yamamoto 4 1Tokushima Health Screening Center, Tokushima, Japan 2KKR Takamatsu hospital Health Medical Center, Takamatsu, Japan 3Department of Medical Screening Center, Kagawa Prefectural Central Hospital, Kagawa, Japan 4Department of Central Clinical Laboratory, Kagawa Prefectural Central Hospital, Kagawa, Japan Keyword: Helicobacter pylori未感染胃癌 , Helicobacter pylori陰性胃癌 , 検診 , 時代的変遷 , 胃腫瘍 pp.841-853
Published Date 2014/5/25
DOI https://doi.org/10.11477/mf.1403114172
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 As the Helicobacter pylori(Hp)infection rate decreases, gastric cancer patients with no history of Helicobacter pylori infection “(i.e., Hp-uninfected gastric cancer)”may show a relative increase in incidence. Gastroenterologists, particularly those involved in gastric cancer screening, are therefore required to have adequate knowledge about the frequency and features of Hp-uninfected gastric cancer. In our study, the frequency of Hp-uninfected gastric cancer was quite low, accounting for 6(0.7%)of all patients with gastric cancer encountered at our facility(n=822). When analyzed historically, the frequency has recently increased, with 1 patient(0.7%)recorded during Period III(2001-2005)and 5(3.1%)recorded during Period IV(2006-2010). Endoscopically, Hp-uninfected gastric cancer is often visualized as a well-demarcated color-faded dim lesion(type 0-IIb)within the fundic gland region. Its detection is relatively easy if screening is performed carefully, even in patients without Hp infection. An ultra-small diameter endoscope is also a useful tool for detecting lesions in Hp-uninfected gastric cancer. It is also necessary to study the natural course of these Hp-uninfected gastric lesions.

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