Clinical Feature of Helicobacter pylori-negative Gastric Cancer Masanori Ito 1 , Atsunori Sasaki 2 , Masana Tatsugami 1 , Akemi Takamura 1 , Shiro Oka 3 , Shunsuke Takata 1 , Shinobu Imagawa 1 , Yoshiaki Matsumoto 1 , Yoshihiro Wada 1 , Shosuke Kitamura 1 , Shinji Tanaka 3 , Masaharu Yoshihara 4 , Kazuaki Chayama 1 1Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan 2Department of Internal Medicine, Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan 3Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan 4Health Service Center, Hiroshima University, Hiroshima, Japan Keyword: Helicobacter pylori , 陰性胃癌 , 組織学的胃炎 , 内視鏡診断 pp.981-988
Published Date 2007/5/25
DOI https://doi.org/10.11477/mf.1403101116
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 Only 1 % of patients with gastric cancer(GCa)were diagnosed as Helicobacter pylori-negative. H. pylori-negative GCa has developed not only in younger but also in elder people, and its prevalence was relatively higher in female than in male. Endoscopically, it appears as a flat depressed tumor and is diagnosed as diffuse type carcinoma histologically. Gastric cancer develops even after eradication therapy and its typical feature is flat depressed cancer with intestinal type appearance. It should be noticed that one third of these tumors become indistinct after eradication therapy especially in cases with flat elevated type GCa. In these tumors, non-atypical regenerative epithelium covers over the tumor and this makes it more difficult to diagnose these tumors.

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