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要旨 29歳以下に発生する胃癌は全胃癌例中0.1%程度のまれな病態であり,そのほとんどが未分化型癌の組織像を呈する.その発症には,中高年の胃癌と同様,Helicobacter pylori感染が重要な役割を果たす.症例対照研究では,若年者胃癌におけるH. pylori感染のodds比は23.5と算出され,中高年胃癌におけるodds比より高値となる.若年層においてH. pylori感染者は徐々に減少傾向にあるが,たとえ若年者であっても感染者には萎縮性胃炎が既に存在し,胃癌の発生母地となる.特に結節性胃炎症例では,体部胃炎を伴い未分化型胃癌の高危険群として臨床的に重要である.
Among all gastric cancer patients, cases less than 30 years old are extremely rare. In these patients, most cancer tissues were histologically diagnosed as diffuse type cancer.
Helicobacter pylori infection plays an important role in gastric carcinogenesis in young as well as in older patients. Higher odds ratio of H. pylori infection was obtained in the development of young gastric cancer compared with that of cases of more elderly patients. Atrophic gastritis has already been found even in young patients with H. pylori infection. Nodular gastritis with corpus gastritis is an important status as a high risk condition for gastric cancer development in the young.
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