Cronkhite-Canada Syndrome with a Remarkable Improvement, Report of a Case Takashi Kumamoto 1 , Ken Haruma 1 , Kouji sumii 1 , Goro Kajiyama 1 1The First Department of Internal Medicine, Hiroshima University, School of Medicine pp.551-558
Published Date 1986/5/25
DOI https://doi.org/10.11477/mf.1403110314
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The patient, a 64 year-old man, went to a hospital with complaints of anal discomfort and edema of the lower extremitles and was found to have a polyposis and giant rugae in the stomach. He was admitted to our hospital for further survey and treatment, No particular family histories were found. He had slight degree of hair loss, atrophy of the nails, edema of the lower extremities, and prolapsed anus with hypertrophied mucosa. Laboratory investigation revealed marked proteinuria, hypoprotinemia, anemia, and malabsorption of the saccharides and lipids. 125I-PVP test was normal So hypoproteinemia was thought to be due to the proteinuria. Radiographic examination of the stomach showed a polyposis with giant rugae. Barium enema x-ray study revealed many sessile round polyps. Histologically cystic dilatation of the glands and hyperplasia were recognized in the gastric polyps and the colonic polyps. In addition, in the colonic polyps adenomatous changes were seen. Histological examination of the prolapsed anus also revealed hyperplastic changes. In the kidney membranous changes of the glomerulus were histologically recognized. He received methylprednisolone pulse therapy and showed a dramatic improvement of proteinuria, polyposis of the stomach and the colon, and of atrophy of the nails after eight months of the therapy.

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