Cronkhite-Canada Syndrome with a Giant Villous Tumor of the Stomach-Developing Cancerous Change, Report of a Case Yasufumi Uchida 1 , Tatsuro Kisu 1 , Hisao Mori 1 , Kotaro Yamaoka 1 1Division of Gastroenterology, Department of Internal Medicine, Saga Medical School pp.559-563
Published Date 1986/5/25
DOI https://doi.org/10.11477/mf.1403110316
  • Abstract
  • Look Inside

 A 50 year-old woman was admitted to our hospital because of generalized edema and exertional dyspnea due to severe anemia(Hb 3.1g/dl). Physical examination revealed the atrophy of nails and loss of hair, but pigmentation was not seen. Hypoproteinemia was remarkable(Total Protein 3.7g/dl)and 125I-PVP test(4.6%) suggested protein-losing gastroenteropathy. The upper gastrointestinal series showed multiple small polypoid lesions in the stomach and a fist-sized tumor with soap-bubble appearance was recognized in the second part of the duodenum, but polyposis of the large intestine could not be seen. The gastroduodenofiberscopy revealed multiple polypoid lesions resembling salmon roe in the stomach and a huge villous tumor in the duodenum.

 As the specimen of the biopsy suggested malignant change, wedge resection including the villous tumor was performed. In the histological findings the excised tumor(10×8cm,160g)showed typical findings of Cronkhite-Canada(C-C)syndrome, where wide and edematous interstitium and cystically dilated glands were seen. A small part of the villous tumor revealed a cancerous change, which was diagnosed as welldifferentiated adenocarcinoma. As the typical part of C-C syndrome transferred continuously to the cancer, we inferred that it was the tubulovillous adenoma of C-C syndrome that transferred to the cancer,Only 12 cases have been reported about carcinoma which was associated with C-C syndrome. Relationship between C-C syndrome and its cancerous change has not been established yet, but we believe that there is likelihood of cancerous change in C-C syndrome.

Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院


  • Cronkhite-Canada症候群 今村 哲理 , 栃原 正博 , 安保 智典 , 黒河 聖 , 吉田 未央 , 石井 卓 , 西岡 均 , 須賀 俊博 , 村島 義男 , 加藤 元嗣 , 穂刈 格 , 浅香 正博 医学書院 胃と腸
    35巻 3号 (2000年2月)
    • 有料閲覧
  • Cronkhite-Canada症候群 山本 佐織 , 長田 厚 , 小嶋 裕一郎 , 塚本 克彦 協和企画 皮膚病診療
    37巻 4号 (2015年4月)
    • 有料閲覧
  • Cronkhite-Canada症候群 松村 泰宏 , 平田 央 , 前川 直輝 , 國行 秀一 協和企画 皮膚病診療
    37巻 4号 (2015年4月)
    • 有料閲覧
  • Cronkhite-Canada症候群の1例 岩崎 加代子 , 奥 知三 , 木田 実 , 小島 紘一 医学書院 臨床皮膚科
    47巻 12号 (1993年11月)
    • 有料閲覧
  • Cronkhite-Canada症候群の1例 佐藤 涼子 , 落合 豊子 , 安藤 浩代 , 森岡 貞雄 , 伊藤 和郎 , 富田 寛 医学書院 臨床皮膚科
    43巻 7号 (1989年6月)
    • 有料閲覧