Cronkhite-Canada Syndrome Associated with Adenosquamous Carcinoma in Gastric Polyps, Report of an Autopsy Case S. Yokoyama 1 , H. Yamashita 1 , A. Moriuchi 1 , Y. Mochizuki 1 , Y. Nakamura 2 , H. Watanabe 2 , K. Tsuji 3 1Department of Pathology, Oita Medical College 2Department of Surgery, Oita Prefectural Hospital 3Department of Pathology, Oita Prefectural Hospital pp.981-985
Published Date 1983/9/25
DOI https://doi.org/10.11477/mf.1403109349
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 A 70 year-old man was admitted to the hospital with chief complaints of anorexia, weight and hair loss, and atrophy of finger and toenails. Pigmentation of skin and oral mucosa was not observed. Laboratory studies revealed hypoproteinemia of 5g/dl and a hard and irregular mass was palpable in the epigastrium. X-ray and endoscopic examination showed innumerable polyps of varying size and a large cauliflower-like lesion in the antrum. Biopsy specimens obtained from the cauliflower-like lesion revealed adenosquamous carcinoma, and thus the patient had a partial gastrectomy on June 23, 1980. Histological examinations of the resected stomach showed numerous polyps consisting of cylindrical epithelium, cystically dilated glands containing mucus, and edematous stroma with infiltration of inflammatory mononuclear cells. Some polyps showed hyperplasia of surface and foveolar epithelium, which resembled adenomatous polyps. Hyperplasia of surface and foveolar epithelium showing cellular atypia of moderate degree in the area surrounding adenosquamous carcinoma were marked. These features suggest that same polyps in Cronkhite-Canada syndrome have a possibility to show malignant transformation. After the operation, his hair and nails grew again, however, the patient died of massive metastasis of adenosquamous carcinoma to the liver on December 11, 1980. At autopsy, polyps were observed only in the remnant stomach.

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