The Differences of H. pylori Positive Peptic Ulcer between Young Subjects and Middle-aged or Older Ones Katsuhiro Mabe 1 , Mototsugu Kato 2 , Mio Suzuki 1 , Saori Ishigaki 1 , Masahira Haneda 1 , Masakazu Takahashi 1 , Shouko Ono 2 , Yuichi Shimizu 1 , Yasuaki Mori 3 , Manabu Nakagawa 4 , Souichi Nakagawa 4 , Takahiko Kudo 5 , Hiroaki Takeda 6 , Harufumi Oizumi 7 , Masahiro Asaka 8 1Department of Gastroenterology, Hokkaido University Hospital, Sapporo, Japan 2Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan 3Internal Medicine and Gastroenterology, Mori Gastroenterological Clinic, Yoichi, Japan 4Nakagawa Ichouka Clinic, Sapporo, Japan 5Ebetsu Hospital, Ebetsu, Japan 6Division of Endoscopy, Yamagata University Hospital, Yamagata, Japan 7Internal Medicine, Oizumi medical clinic, Yamagata, Japan 8Department of Cancer Preventive Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan Keyword: Helicobacter pylori , 消化性潰瘍 , 若年者 , 高齢者 , NSAIDs pp.1333-1339
Published Date 2011/8/25
DOI https://doi.org/10.11477/mf.1403102328
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 The differences of H. pylori positive peptic ulcer between young subjects(less than 30 years)and middle-aged or older ones were investigated using the data of a large-scale clinical study in Yamagata prefecture and endoscopic and histological data in the Hokkaido University Hospital. The proportion of H. pylori positive ulcer is higher and that of NSAIDs ulcer is lower in young subjects than in the middle-aged or elderly subjects. Young subjects have mainly antrum predominant gastritis and duodenal ulcers. On the other hand, corpus-predominant gastritis increases and also corpus ulcers in the middle-aged and eldely are increased. Higher rate of ulcer recurrence after H. pylori eradication in the elderly is associated with deep ulcer, NSAIDs use, and a background of diabetes. Therefore, careful treatment and endoscopic surveillance is necessary in these patients even after successful of eradication.

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