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要旨 H. pylori陽性消化性潰瘍患者における30歳未満の若年者と中高年者の違いについて,山形県における大規模臨床研究と北海道大学病院における内視鏡と組織学的検討の成績を用いて検討した.若年者の消化性潰瘍は中高年者と比較して,H. pylori陽性率が高く,NSAIDs起因性潰瘍など薬剤性潰瘍が少ない.若年者は前庭部優勢胃炎が多く,十二指腸球部に潰瘍発生が多い.一方,中高年では凡胃炎から体部優性胃炎が多く,潰瘍は胃角部から胃体部に発生する.除菌治療後の潰瘍再発率は高齢男性,深掘れ潰瘍,糖尿病などで有意に高く,これらの症例では除菌治療後も再発に注意が必要である.
The differences of H. pylori positive peptic ulcer between young subjects(less than 30 years)and middle-aged or older ones were investigated using the data of a large-scale clinical study in Yamagata prefecture and endoscopic and histological data in the Hokkaido University Hospital. The proportion of H. pylori positive ulcer is higher and that of NSAIDs ulcer is lower in young subjects than in the middle-aged or elderly subjects. Young subjects have mainly antrum predominant gastritis and duodenal ulcers. On the other hand, corpus-predominant gastritis increases and also corpus ulcers in the middle-aged and eldely are increased. Higher rate of ulcer recurrence after H. pylori eradication in the elderly is associated with deep ulcer, NSAIDs use, and a background of diabetes. Therefore, careful treatment and endoscopic surveillance is necessary in these patients even after successful of eradication.
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