Gastrointestinal Polyposes and Malignant Tumor Takayuki Matsumoto 1 , Yuji Maehata 1 , Kentaro Shikata 1 , Kiyoshi Fujisawa 1 , Kazuoki Hizawa 2 , Minako Hirahashi 3 , Mitsuo Iida 1 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Internal Medicine, Kyushu Central Hospital, Fukuoka, Japan 3Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Keyword: Peutz-Jeghers症候群 , 若年性ポリポーシス , Cowden病 pp.665-670
Published Date 2010/4/30
DOI https://doi.org/10.11477/mf.1403101916
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 Hereditary hamartomatous polyposes are diseases prone to develop into malignant neoplasms. In Peutz-Jeghers syndrome, malignant tumors occur predominantly in the gastrointestinal tract, in the pancreas and in the breast, where as the thyroid, the breast and the uterus are the sites of involvement in Cowden's disease. In contrast, the gastrointestinal cancers are the major tumors in Juvenile polyposis, especially at the site of severe polyposis. Among non-hereditary polyposis syndromes, colorectal cancer and adenomas frequently occur in Cronkhite-Canada syndrome.

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