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A young case of rapidly fatal nasopharyngeal carcinoma due to diffuse liver metastasis Miki Takahara 1,3 , Seiji Shigetomi 1 , Hideki Orikasa 2 , Hiroyuki Ozawa 3 1Department of Otolaryngology, Kawasaki Municipal Hospital 3Department of Otolaryngology, Keio University School of Medicine Keyword: びまん性肝転移 , 導入化学療法 , EBV-DNA pp.629-633
Published Date 2025/7/20
DOI https://doi.org/10.11477/mf.091434910970080629
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 A 27-year-old man was initially diagnosed with undifferentiated nasopharyngeal carcinoma (cT3N3M0) and underwent concurrent chemoradiotherapy. The primary tumor and right lymph nodes disappeared after treatment. Although adjuvant chemotherapy was planned, the patient rapidly developed liver failure and died 46 days after chemoradiotherapy due to diffuse liver metastasis.

 This type of nasopharyngeal carcinoma is most common among young patients and is highly sensitive to radiation; however, distant metastasis results in a poor prognosis. Early detection of distant metastases is crucial, and induction chemotherapy and the measurement of plasma EBV DNA levels can be helpful.


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電子版ISSN 1882-1316 印刷版ISSN 0914-3491 医学書院

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