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Suspected non-infectious intraocular inflammation with retinal vascular occlusion after intravitreal faricimab treatment: a case report Takemi Sugiyama 1 , Satoru Inoda 1 , Hidenori Takahashi 1 , Hana Yoshida 1 , Hironori Takahashi 1 , Manami Misawa 1 , Takuya Takayama 1 , Daizo Matsumoto 1 , Shoma Tsuchiya 1 , Toshikatsu Kaburaki 1 1Department of Ophthalmology, Jichi Medical University pp.1005-1010
Published Date 2025/8/15
DOI https://doi.org/10.11477/mf.037055790790081005
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Abstract Purpose:To report a case of intraocular inflammation(IOI) with concurrent retinal arteriovenous occlusion following intravitreal faricimab(IVF) injection.

Case:A 77-year-old man presented with type 1 macular neovascularization secondary to untreated neovascular age-related macular degeneration(nAMD) in the left eye. After receiving 13 intravitreal aflibercept injections and one half-dose of photodynamic therapy at our hospital, his condition stabilized, and he was referred to his previous ophthalmologist. Following disease recurrence, he received multiple aflibercept injections at the referral clinic. Due to recurrences, he was referred back to our hospital, where he received five intravitreal brolucizumab injections. Due to the continued recurrences, the treatment was switched to IVF. Eleven days after the fourth IVF injection(319 days after the initial injection), the patient reported visual field constriction. Fourteen days later, the decimal best-corrected visual acuity(BCVA) in the left eye decreased from 0.5 to 0.4. While the anterior segment and vitreous were unremarkable, fundoscopic examination revealed white sheathing of the superotemporal retinal artery emanating from the optic disc, accompanied by retinal ischemic changes. Fluorescein angiography confirmed a branch retinal arteriovenous occlusion in the corresponding retinal area. A 20-mg sub-Tenon injection of triamcinolone acetonide was administered for suspected IVF-induced IOI with retinal artery occlusion. One month after treatment, the patient's subjective symptoms improved, with partial resolution of the white sheathing of the retinal artery. The inferior visual field defect improved, and BCVA recovered to 0.7. Although the branch retinal venous occlusion resolved, white sheathing of the retinal artery persisted.

Conclusion:IOI with concomitant retinal arteriovenous occlusion associated with IVF has been reported.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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