耳下腺部軟部好酸球肉芽腫の治療法に対する1考察—病理組織学的所見からみた術前照射の意義

Pre-operative Irradiation of Eosinophilic Granuloma in the Parotid Area

I．緒言

　本論文の要旨は，境界不明瞭な耳下腺部軟部好酸球肉芽腫に対し，少線量の術前照射により，腫瘍周辺に結合織の被膜をつくり，完全摘出を容易にすることができるか否かを検討したものである。

　耳下腺部における軟部好酸球肉芽腫の治療は，副腎皮質ステロイドあるいは，放射線照射による保存的療法と浜術的療法によるものとに大別される。しかし保存的療法のみでは根治が難しく，また手術的療法では出血しやすいため，完全摘出が困難であるという報告が多く，さらに放射線やステロイドと手術の併用療法も個人によりまちまちで，治療に一貫性がみられていないのが現状である。

　Eosinophilic granuloma is thought to originate in the reticuloendothelial system and cannot clearly be distinguished from the surrounding tissue during operation.

　An eosinophilic granuloma in the parotid area was removed after 25 days of irradiation at a dosage of 10.0 Gy per 3 days. A thin capsule of connective tissue was observed after the tumor was cut in half. Then, histopathological studies were performed onthis connective tissue to determine the effect of the irradiation.

　Histopathologically, at the periphery of the tissue, atrophy of lymphocytes and destruction of the lymphoid tissue, which were thought to result in anincrease in the connective tissue, were observed.

　It was concluded that a small dose of pre-operative radiation on eosinophilic granuloma in the parotid area made the tumor small and produced a capsule around the tumor.