小児における上気道再感染と免疫グロブリン—主として反復性中耳炎の成因から見て

REPEATED UPPER RESPIRATORY TRACT INFECTION AMONG CHILDREN AND IMMUNE GLOBULIN: FROM STANDPOINT OF THE MECHANISM WITH WHICH RECURRENT OTITIS MEDIA OCCUR

　Ⅰ．緒言

　酵素化学および免疫化学の発達とともに，耳鼻咽喉科領域においても免疫グロブリンを主体とした問題が多くなりつつある。

　従来，小児における中耳炎に対しhypogammaglobulinemiaおよびdysgammaglobulinemiaなる言葉が使用されてきたが，最近になりこれらを一括して免疫不全症候群と呼ばれるようになつた（第1表）。

　That there are some interrelation between repeated upper respiratory tract infection among children and the condition in which the blood may be found particularly with IgA secretory deficiency, has been repeatedly reported and recognized. In considering this question of recurrent otitis media among children the question of immunity in the individual may loom as an important factor but it would be erroneus to consider this factor alone as a sole key to the solution.

　As a mater of fact, that the causative factors that may lead to the establishment of middle ear effusion by recurrent middle ear infection have not been clearly revealed; allergy may be considered as an important contributor as well as poor dietary habits leading to protein deficiency, hormonal disturbances and lymphoid hypertrophy.