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THE MIDDLE EAR IMMUNOLOGY: IMMUNOGLOBULIN FORMING CELLS IN THE MIDDLE EAR MUCOSA OF GUINEA PIGS Goro Mogi 1 pp.119-126
Published Date 1980/2/20
DOI https://doi.org/10.11477/mf.1492209040
  • Abstract
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 To clarify the developmental course of the immunological defence system in the middle ear, immunoglobulin forming cells of different classes and secretory proteins, such as secretory component (SC) and lactoferrin (Lf), were investigated in the middle ear mucosa of 20 developing and 5 normal adult guinea pigs by use of direct immunofluorescence technique. Changes in the middle ear mucosa were also observed after antigenic challenges directly to the tympanic cavity of 6 developing and 39 adult guinea pigs.

 IgA and IgM forming cells began to appear in the tubal mucosa at 7 postnatal day, while it was scarcely possible to find IgG1 and IgG2 forming cells in developing guinea pigs. Immunoglobulin forming cells of all classes increased in the middle ear mucosa after the antigenic stimuli. The injection of antigens to the tympanic cavity of developing animals induced the most striking accumulation of immunoglobulin forming cells in the middle ear mucosa.

 Results of this study showed that local synthesis of IgA, as well as other classes, is latent in the middle ear, that the middle ear of immature animals is vulnerable to antigenic stimuli, and that the middle ear of developing animals possesses potential immune responsiveness.


Copyright © 1980, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 印刷版ISSN 0386-9679 医学書院

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