兎唇口蓋破裂の遺傳に関する調査

　私共が日常，兎唇・口蓋破裂の患児を多数取扱つて居ると，「兎唇はどの程度遺伝するものか」とか，「次も同じような子供が生れるか」等々の質問に屡々接する．畸型児を持つ親達にとつてみれば切実な悩みであるが，その返答にははたと窮してしまう．兎唇・口蓋破裂は余り濃厚な遺伝関係を示すものではないと識りつゝも，「次の子供は絶対に大丈夫ですよ）と断言する自信もない訳である．この点に就ては，従来多数の報告がなされて来たが，私共は自験例について，果してこの種畸型の遺伝関係がどうなつておるか，を究明し度く，この小集計を企図したのである．即ち昭和23年より26年10月迄の手術例156患者の家系について調査した．統計母数として甚だ貧弱ではあるが，よく吟味された症例の観察であるので，同好の士の参考資料ともなればと思い，敢て報告する次第である．

TAGUCHI AND NAGAI investigated 156 ca-ses of hare lip and cleft palate which were mani-fested with hereditary nature. Numerically there were more males affected than the females; and the combined type of affliction which included the lip and the palate exceeded in incidence than tho-se in whom either hare lip or cleft palate were found alone. With oral malformation there were found other congenital abnormalities, especially, hernia which occurred in 15.3 per cent in this series. This figure is definitely higher than its usual occurrence. The family history of the affli-cted revealed marriages of the ancestors in closer kinship than such ordinarily take place. Other congenital abnormalities were discovered in the progenitors but factors that might have influenced the malformation at the time of conception or du-ring the period of pregnancy were not established.