チフス豫防接種後に發現せる顆粒細胞減滅症の2例

　顆粒細胞減滅症なる疾患はSchulzがその初め提唱した樣な單一独立の疾患ではなくて，種々な原因乃至は誘因に依つて惹起される場合の多いことは，既に充分明らかな所である．而して之等原因たる種々なものゝ中には，吾々が実に意外に思う樣な藥物の作用又は疾病或いは物理的器械的刺戟等があることは，幾多内外の文献に見る所である．1929年Bromberg及びMurphyによつて報告されたチフス予防接種に因る本症の如きも，亦その中の一ツであろうと思う．私は腸チフス，パラチフス混合ワクチンの皮下注射後に引つづき，兄弟2名の学童に発現した本症と老えられる2症例に相違し，甚だ珍らしい症例と思い茲に之を報告する次第である．

Kurihara cites two cases of agranulocytosis which was clinically manifested, in children who were brothers, by necrotic tonsillitis;the dia-gnosis was attained by blood examination, The onset of the dlsease closely followed the time when on June 14,1949, group immunization against typhus fever was conducted to children in a primary school where two brothers were a part.

Various etiological basis has been considered: (1) the character of immunizing agent; (2) con-ditions under which the immunization was con-ducted; (3) patients'tendency towards idiosycra-cies; and, (4) character of the blood picture. But, it was concluded that the most likely cause of this disease be the condition, in accordance to concellsus, of want is known as that of "manifestation of drug allergy in children who are physically weak in health". to which point the cases seemed to have served to illustrate.