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Contrast-enhanced MRI findings as related to pain and visual outcome in acute optic neuritis Mitsuhiro Matsuzaki 1,2 , Masataka Shimozono 3 , Yasuhiko Hirami 1,2 , Fumitaka Hirose 1,2 , Noriko Miyamoto 1,2 , Akihiro Nishida 1,2 , Masashi Kikuchi 1,4 , Yasuo Kurimoto 1,2 1Department of Ophthalmology, Kobe City Medical Center General Hospital 2Department of Ophthalmology, Institute of Biomedical Research and Innovation 3Department of Ophthalmology, Osaka City General Hospital 4Kikuchi Eye Clinic pp.1259-1263
Published Date 2016/8/15
DOI https://doi.org/10.11477/mf.1410211914

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Abstract Purpose: To report contrast-enhanced MRI findings in acute optic neuritis as related to pain and visual outcome.

Cases and Method: This retrospective study was made on 29 cases of acute optic neuritis who were treated by us in the past 8 years. The series comprised 5 males and 24 females. The age averaged 44 years. Sixteen cases were diagnosed with idiopathic optic neuritis, 8 cases with multiple sclerosis, and 5 cases with neuromyelitis optica. All the cases were evaluated by contrast-enhanced MRI to identify the location of the lesion and its anteroposterior extent. Visual acuity was evaluated in terms of logMAR.

Findings and Clinical Course: The causative lesion was located in the orbit in 23 cases and out of the orbit in 6 cases. Pain was present in 20 cases and all had causative lesion in the orbit. Six cases who felt no pain had causative lesion out of the orbit. The difference was significant(p<0.001). Extent of the lesion along the optic nerve was significantly related with visual acuity before or after treatment. Visual outcome was poor when the lesion extended for 20 mm or over.

Conclusion: Cases of acute optic neuritis showed significantly more frequent pain when the lesion was located in the orbit. Cases with extensive lesion showed poor visual outcome.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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