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The relationship between the distribution in the macula and the platelet function or visual acuity in Behçet disease Itsuko Sugihara 1 , Hideaki Yoshino 1 , Teruo Nakamura 1 , Yasuhiro Ikuta 1 , Nobuyuki Sugihara 2 , Yoriko Suga 3 1Dept. of Ophthalmol, Yamaguchi Univ Sch of Med 2Second Dept of Inter Med, Yamaguchi Univ Sch of Med 3Dept of Ophthalmol, Hosp of Yamaguchi Saiseikai pp.927-931
Published Date 1987/8/15
DOI https://doi.org/10.11477/mf.1410210137

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  • Abstract
  • Look Inside

To investigate the obstructive arteriolitis of ocu-lar vessels in Behçet's disease, we divided the patients into the three groups : Group I (Behçet'sdisease : n=11), group II (Harada's disease of the uveitis without any vasculitis ; n=9) and Group III ('Control' patients without any vasculitis nor uveitis ; n=11).

Using a computer-assisted image analysis of fluorescein angiography, the region of interest (ROI) was positioned over the macular region after the size of ROI was calibrated by the diameter of optic disc. We measured a number of the terminal branches of arterioles in ROI by the visual inspec-tion. After the border edge of arterioles was enhan-ced by the differential function, we calculated a ratio per mil of the area of arterioles in ROI to the area of ROI itself. We correlated this ratio of area with visual acuity and platelet function in 8 patientsof Group I . The results were as follows : 1) A number of the terminal branches in Group I (4.5±2.5 : meant±SD) was decreased more than those in both Group II (6.3±1.9) and Group III (6. 0±2.0), but not significant. 2) The area ratio in Group I (16.1±9.3%) was reduced more than those in Group II (23.7±8.3%, NS) and Group III (30.5± 11.4%, p<0.01). 3) The visual acuity was de-creased in proportion to the reduction of area ratio in Group I. 4 ) The platelet function (retention and aggregation by adenosine diphosphate of 1.0, 3. 0 pM) was increased in patients with the reducedratio of area in Group I.

These results suggested that the thrombotic obstruction and/or stenosis of ocular arteriolitis in Behcet's disease may be probably due to the ab-nomalities of platelet function, and may cause the decrease in visual acuity.

Rinsho Ganka (Jpn J Clin Ophthalmol) 41(8) : 927-931, 1987


Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.

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