雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

Brain and Nerve No to Shinkei Volume 29, Issue 9 （September 1977）

Brain and Nerve 脳と神経 29巻9号（1977年9月発行）

Japanese English

原著

末梢静脈血漿cyclic AMPによる脳梗塞障害度の早期評価 EARLY ESTIMATION OF EXTENT OF THE LESION IN CEREBRAL INFARCTION BY MEANS OF CYCLIC AMP CONCENTRATION IN PERIPHERAL VENOUS PLASMA 冨永詩郎 ¹ , 小嶋俊一 ¹ , 村上松太郎 ¹ , 上村和夫 ² , 鈴木敏巳 ¹ , 中村隆 ¹ Shiro Tominaga ¹ , Shunichi Kojima ¹ , Matsutaro Murakami ¹ , Kazuo Uemura ² , Toshimi Suzuki ¹ , Takashi Nakamura ¹ ¹秋田県立脳血管研究センター内科 ²秋田県立脳血管研究センター内科放射線科 ¹Divisions of Internal Medicine, Research Institute of Brain and Blood Vessels ²Divisions of Internal Radiology, Research Institute of Brain and Blood Vessels pp.987-993

発行日 1977年9月1日 Published Date 1977/9/1

DOI https://doi.org/10.11477/mf.1406204132

PDF(4609KB)

有料閲覧

閲覧方法のご案内

この論文を閲覧するためにはログインが必要になります。

パスワードを忘れた場合新しくユーザー登録する施設共通IDをご利用の方はこちらから

PPV購入案内

1,320円 (1,200円+税10%) こちらは、987ページから993ページの文献です。

PPV（ペイ・パー・ビュー）とは、論文（記事）単位で購入・閲覧ができるサービスです。
購入には医書.jp本会員登録が必要です。

新規会員登録はこちらから

会員登録完了後に改めて上記「購入サイトへ」を選択してください。
または「購入サイトへ」選択後に「購入ログイン」、「新規会員登録」の順に進んでください。

会員登録について詳しくは

こちら

をご確認ください。

Abstract 文献概要
1ページ目 Look Inside

I．はじめに

　末梢静脈血漿（以下PVPと略す）におけるcyclicAMP濃度の経時変化が，脳血管障害の病型によつて異なり^19,20），脳梗塞では，この変化が脳シンチグラム上の異常範囲と関連のある事を，我々はすでに示唆した^20,21）。

　この論文では，脳梗塞患者のPVPにおけるcyclicAMP濃度の経時変化と，脳シンチグラム上の異常範囲との相関を検討し，cyclic AMPの濃度が変動するメカニズムについても考察を加える。

Subjects consisted of fifteen patients with cerebralhemispheric infarction who were admitted to thehospital within three days after the onset. Ante-cubital venous blood was sampled in the presenceof 0.5 M EDTA. Plasma was obtained by centri-fugation and was analyzed for cyclic AMP applyinga competitive protein binding method without anypretreatment. Brain scintigraphy was performedusing ^99mTc pertechnetate 12-19 days after theonset, except for three patients who were investi-gated 22-36 days after the onset. The size of ab-normal uptake of isotope was expressed as percentto the cross-sectional area of the intracranial spacein the lateral and the frontal (anterior or posterior)views.

1) In three patients with mild dysarthria, hemi-paresis and no disturbance of consciousness, con-centration of cyclic AMP in the peripheral venousplasma (PVP) remained in the normal range (8-18picomoles/ml) throughout the observation for 15days. This group showed no abnormal isotopeuptake in scintigrams.

2) Patients with any disturbance of consciousnessand apparent neurological deficits were divided intotwo groups according to the nature of time coursesof cyclic AMP concentration. In one group cyclicAMP concentration in PVP decreased to subnormalrange within several days after the onset, and inthe other group it remained in the normal range.

3) In the former group (4 patients), the size ofthe region of abnormal isotope uptake in scintigramswas 5-26% and 8-16% of the cross-sectional areaof the intracranial space in the lateral and in thefrontal views, respectively.

4) In the latter group (7 patients) the size ofthe lesion was over 24% and 16% in the lateraland in the frontal views, respectively. In thisgroup there was an exceptional patient who had asmall lesion. However, it was located in the basalganglionic region and neurological deficit wassevere.

5) With the time course of the level of cyclicAMP in PVP, it is probable that we can estimatethe extent of the lesion within several days afterthe onset of cerebral hemispheric infarction, whereasit usually takes more than a week by means ofbrain scintigraphy.