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DISTRIBUTION OF ALZHEIMER'S NEUROFIBRIL-LARY TANGLES IN THE BASAL GANGLIA AND BRAIN STEM OF PROGRESSIVE SUPRANUCLEAR PALSY AND ALZHEIMER'S DISEASE Hiroshi Ishino 1 1Department of Neuropsychiatry, Okayama University Medical School pp.601-605
Published Date 1975/6/1
DOI https://doi.org/10.11477/mf.1406203721

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  • Abstract
  • Look Inside

The author studied the distribution of neuro-fibrillary tangles in the basal ganglia and brain stem of progressive supranuclear palsy and Alzheimer's disease, with the result that almost no similarity in the distribution and density of neurofibrillary tangles exists between both diseases.

In two cases with progressive supranuclear palsy neurofibrillary tangles were found most numerously in the subthalamic nucleus. Next in order came the globus pallidus, reticular formation of mid brain, pons and medulla oblongata, pontine nuclei, locus coeruleus, red nucleus, substantia nigra, periaq-ueductal grey matter and olivary nuclei. Neuro-fibrillary tangles were rare in the thalamus.

In two cases with Alzheimer's disease neuro-fibrillary tangles were found most numerously in the nucleus mamilloinfundibularis, nucleus basilaris, nucleus dorsalis raphé, nucleus centralis superior, and next in order came the thalamus. They were found scarcely in the lenticular nuclei and reticular formation of the pons.

In both diseases almost no neurofibrillary tangles were found in the nucleus supraopticus, nucleus paraventricularis, nuclei tuberales and nuclei cor-poris mamillare.


Copyright © 1975, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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