Tracer Microsphere法による臓器血流量測定ことに長期測定実験の信頼性について

Serial estimation of organ blood flow with Tracer-Microsphere method:Confidence in chronic experiments

　臓器・組織の血流量測定は，病態生理・薬理作用などの解明のための有力な手段として，臨床・実験の両面で広く用いられている。その測定法は臓器の種類や目的などにより異なるが，現在以下のような方法が用いられている^1）。

　I：血管の血流量測定法として，1）適数法，2）電磁流量計，3）超音波流量計，4）流速計，5）赤血球流速測定法などがある。

1) The serial estimations of organ and/or tissue blood flow of mongrel dogs were performed three times at intervals of fifteen minutes each other. The dogs were anesthetized and mechanically ventilated, and their hemodynamics and blood gases were maintained almost the same conditions throughout the experiments. Blood flow distri-butions to the organ and/or tissue measured ranged within 10 to 15% of variation. However, there was no significance between the estimations in all organ and/or tissue blood flow.

2) The serial estimation of organ and/or tissue blood flow of mongrel dogs were done three times at intervals of about two weeks each other. The first measurement was performed three to five days after the thoracotomy, so the dogs were in conscious and restrained conditions. The second and third estimations carried out 12 to 14 days after the preceding one in almost the same con-ditions. The blood flow to the organ and/or tissue measured showed fairly variations between each estimations. However, no significant change was observed in each measurement of organ and/ or tissue blood flow.