Hemodynamics of Experimental Coronary Artery Occlusion

　The almost classic experimental approach　to the problem, the coronary artery occlu-sion in dog and other animals has been　used as an experimental model for myo-cardial infarction in man．　Experiments in　animals with normal coronary arteries may　not necessarily explain the sequelae of the　acute event in man, in whom coronary　occlusion and infarction are usually the　culmination of a long-standing process of　atheromatosis and sclerosis．

　Nevertheless they show basic physiologic　and pathophysiologic pattern, which are by　reproduction in animals of great help and　value to elucidate the event of coronary　artery occlusion in man．　In the interpreta-tion of the data, derived from animal ex-periments, it is every time the better choice　to be very cautious and careful in compar-ing these results and conclusions with the　clinical data．　The incidence and kind of　manifestations following experimental coro-nary artery occlusion varies greatly in stu-dies by different investigators, by different　methods, by different animals, and even in　different series of experiments by the same　investigator．