本態性高血圧症の心肺動態及び変圧剤（降圧剤，昇圧剤）の心肺動態に及ぼす影響

The cardio-pulmonary dynamics in essential hypertension and the effect of blood pressure altering drugs upon the dynamics.

I．緒言

　近年わが国においても本態性高血圧症の死因として心臓死の急激な増加が指摘されるようになつたが，本症の肺循環系の障害生理を血液動態のみならず，気相，さらに肺胞機能の面より綜合的に研究することは，高血圧性心疾患の発生機序を明かにし，経過を知る上に興味あるところである。

　われわれは最近本態性高血圧症について，その心肺動態を観察し，さらに各種変圧剤の心肺動態に及ぼす影響を追求し得たので報告する。

The cardio-pulmonary dynamics in essential hypertension were studied by using right heart cathe-terization.

The disturbances were found in the aspects of hemodynamics, factors concerning gas phase, and alveolar functions.

The essential hypertensives were classified into 3 groups according to the E. C. G. finding: A-normal in E. C. G., B-intermediate between A and C, C-typical left ventricular hypertrophy.

The disturbances of the cardiopulmonary functions were minimal in group A, moderate in group B and markedly advanced in group C.

This indicates that the back-pressure effect caused by the systemic hypertension aggravates the pulmonary circulation extremely in group C. Consequentry, we belive that it is clinically important to detect the transition period from group B to C by frequent E. C. G. check-ups.

The early effects of the drugs altering blood pressure, namely C₅, C₆, Pendiomide, Reserpine, Veriloid, Apresoline, Chlorpromazine, Aminophylline, Noradrenaline and Adrenaline on cardio-pulmo-nary dynamics were also studied and discussed from the various points of view.

In general, it seemed that the agents causing elevation of the pulmonary arterial pressure had good influences on cardio-pulmonary dynamics, whereas the agents depressing the pulmonary arterial pressure had bad influences.