心肺疾患に対する運動負荷の影響（第2報）

Effects of exercise test upon cardiopulmonary diseases (2nd report)

Ⅰ．緒言

　運動負荷は生体の酸素需要を増すが，これに対する酸素供給の対応しない時は相対的代謝性アノキシアをおこす。本負荷は主として呼吸循環系の調整において体組織とくに心および骨格筋への酸素供給を増加させるという換気および血液動態上の生理学的変動と，乳酸などの酸性中間代謝産物の蓄積により酸塩基平衡などに影響するという代謝上の生化学的変動を生ぜしめる意義をもつ。先に^1）主として心肺疾患における運動負荷の影響を報告したが，さらに実験方法を一部変え，また実験対象を増したのでここに第2報を報告する。

The same exercise test as previously done in the 1st report (J.J.A.T.S., 4: 172, 1955.) is perfor-med to patients with cardiopulmonary diseases such as pulmonary tuberculosis, pulmonary tumor and valvular heart disease etc.

During exercise increase of cardiac output in mitral stenosis and stenoinsufficiency is small but the mean pulmonary pressure is elevated. These changes become more remarkable, as these diseases get severer according to the classification of New York Heart Association.

The pulmonary blood volume is markedly increased in patients with mitral stenosis and in pati-ents whose one side lung is resected.

Among the patients whose oxygen intake during exercise is small, the increase in ventilation con-tinues even after the cessation of exercise.

The cases with bilateral pleural thickening show marked anoxemia and acidosis during exercise due to restrictive ventilatory insufficiency, while inhaling pure oxygen during exercise, both anoxemia and acidosis is reduced.