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The Prevalence of Sleep-disordered Breathing in Patients with Diabetes Mellitus Hirokazu Tokuyasu 1 , Fumiko Okui 2 , Tomoya Harada 1 , Hirokazu Touge 1 , Kenichi Takeda 1 , Yuji Kawasaki 1 , Toshiaki Kakiba 3 , Toshiaki Sato 3 , Eiji Shimizu 4 1Division of Respiratory Medicine, Matsue Red Cross Hospital 2Division of Laboratory Test, Matsue Red Cross Hospital 3Division of Diabetes and Endocrine Medicine, Matsue Red Cross Hospital 4Division of Medical Oncology and Molecular Respirology, Dpartment of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University Keyword: 糖尿病 , 糖尿病性末梢神経障害 , 閉塞性睡眠時無呼吸症候群 , 睡眠時呼吸障害 , diabetes mellitus , diabetic peripheral neuropathy , obstructive sleep apnea syndrome , sleep-disordered breathing pp.957-961
Published Date 2009/9/15
DOI https://doi.org/10.11477/mf.1404101335

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 The purpose of this study was to determine the prevalence of sleep-disordered breathing (SDB) in 107 diabetic patients, including 66 males and 41 females (mean age, 63.2 years), hospitalized for therapeutic education on diabetes mellitus(DM). Portable polysomnography(PSG)(Pulsleep LS-100; Fukuda Densi Co. Ltd. Japan) was performed on all patients. Next, 24 patients who had an apnea-hypopnea index (AHI) of≧10 were subjected to an overnight PSG. Because we observed a positive correlation between the AHI values determined using the LS-100 unit and overnight PSG, it was estimated that AHI of≧5 obtained by overnight PSG, diagnostic criterion for obstructive sleep apnea syndrome, was equivalent to AHI of≧8 obtained by LS-100. The prevalence ratio of SDB was 73.8%. Among 107 patinets, 78 patients that we could analyze were then divided into 2 groups depending on whether the AHI values obtained by LS-100 were ≧8 (SDB group; 58 patients) or <8 (non-SDB group; 20 patients). There were no significant differences between the 2 groups with regard to body mass index, the duration of DM, and other laboratory data. The sensory nerve conduction velocity of the sural nerve was significantly lower in the SDB group than that in the non-SDB group. Hypoxemia caused by SDB might have played a role in diabetic peripheral neuropathy.


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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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