A Case of Small-cell Lung Carcinoma Treated with Carboplatin plus Etoposide Combination Chemotherapy under Hemodialysis Rinako Yasuda 1 , Katsuhiko Naoki 1,4,5 , Hiroaki Okamoto 1 , Shuko Tsujimura 1 , Tomoki Fujii 2 , Naoya Hida 1 , Hiroshi Kunikane 3 , Kenzo Soejima 4 , Akitoshi Ishizaka 4 , Koshiro Watanabe 1 1Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital 2Department of Medical Oncology, Yokohama Municipal Citizen's Hospital 3Department of Supportive Care Medicine, Yokohama Municipal Citizen's Hospital 4Department of Respiratory Medicine, Keio University School of Medicine 5Center for Comprehensive and Advanced Medicine, Keio University School of Medicine Keyword: 血液透析 , 小細胞肺癌 , 併用化学療法 , hemodialysis , small cell lung cancer , combined chemotherapy pp.963-968
Published Date 2009/9/15
DOI https://doi.org/10.11477/mf.1404101336
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 In recent years there are many patients who undergo hemodialysis because of chronic renal failure. Along with that, cases where lung cancer is discovered in patients undergoing hemodialysis are increasing. However, a standard chemotherapy for lung cancer patients undergoing maintenance hemodialysis has not yet been established with this in mind,we conducted chemotherapy using carboplatin 300mg/m2 (day 1) plus etoposide 50mg/m2 (day 1,3) in a patient with limited-stage small cell lung cancer, who was also receiving maintenance hemodialysis. We investigated 16 small-cell lung cancer cases reported since 2000 in Japan that had been treated with carboplatin and etoposide under hemodialysis for chronic renal failure. Reviewing these cases, it is suggested that most effective schedule would be to use a higher dose in the first course followed by dose reduction as necessary for further courses. Although we were able to treat this case safely, the response was limited to an SD (stable disease). Further study is needed to determine the optimal dosage of each drug for small-cell lung cancer with maintenance hemodialysis.

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