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Definition and Morphological Characteristics of Early Carcinoma of the Gallbladder Hidenobu Watanabe 1 , Hiroshi Kijima 1 , Katsuyuki Uchida 1 1The First Department of Pathology, Niigata University, School of Medicine pp.483-495
Published Date 1986/5/25
DOI https://doi.org/10.11477/mf.1403110293

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  • Abstract
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 We assessed our definition of early carcinoma of the galldladder in 46 cases (53 lesions) which we diagnosed as early carcinoma, using as our criteria the morphological characteristics and the macroscopic differentiation of the carcinoma.

 After a period of four years during which the subjects had been under observation, there was no recurrence and the subjecs were in good health, In the 46 cases, lymph nodal metastases, lymphatic permeation, venous permeation and neural invasion were negatlVe.

 Macroscopically, the 53 carcinomas were composed of 14 polypoid (protruded) type carcinomas (26%) and 39 superficial type ones (74%). There were no depressed type carcinoma.

 Six of the carcinomas were the pedunculated type, but, histologically, all of the six were carcinomas in adenoma and had macroscopic characteristics as show in Figs. 1 and 2. Among the early carcinomas, 40% were IIb type, and 49% were carcinomas of combined macroscoplc type.

 The surfaces of 44 early carcinomas showed papillary, roughly (varously-sized) granular and nodular patterns, and were not lustrous and brown or yollowish brown in color in the formalin-fixed specimens. Five carcinomas were IIb type ranging from smooth and flat to finely granular in pattern. The other four carcinomas were IIb type microcarcinomas measurlng less than 3.0mm.

 We difiened early carcinoma of the gallbladder as “carcinomas limited to the mucosa or to the mucosa and muscle proper (We regard Rokitansky-Aschoff sinus extension as a mucosal extension).” This definition seems to be correct. The carcinomas had macroscopic characteristics by which 85% of them were able to be diagnosed.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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