A Rare Carcinoma of the Gallbladder: A case of endocrine cell carcinoma Masato Haga 1 , Ryoichi Yamakawa 1 , Hiroshi Kijima 2 , Mitsuya Iwafuchi 2 , Hidenobu Watanabe 2 1Department of Internal Medicine, Niigata Kin-ikyo, Kaetsu Hospital 2The First Department of Pathology, Niigata University, School of Medicine pp.223-227
Published Date 1988/2/25
DOI https://doi.org/10.11477/mf.1403107918
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 The patient was a 79 year-old man and was admitted to our hospital complaining of epigastric pain. Ultrasonographic and radiographic examination led us to establishing a diagnosis of the gallbladder carcimoma. He underwent extended cholecystectomy.

 Macroscopically, the resected gallbladder was small, but revealed a nodular infiltraing tumor measuring 25×25×15 mm. Microscopically, the tumor was composed of papillotubular adenocarcinoma and endocrine cell carcinoma. The latter had invaded the liver bed directly. Tumor cells had round vesicular nuclei, and scanty cytoplasm with positive granules shown by Grimelius' method. The endocrine cell carcinoma showed several serotonin, GRP, and gastrin-positive cells shown by PAP method.

 We know only a small number of reports of primary endocrine cell tumor of the gallbladder,25 cases as far as we could trace. The purpose of this paper is to describe clinical and histological characteristics of the endocrine cell carcinoma. We must distinguish endocrine cell carcinoma from the classical carcinoid on the points of cellular atypia, pleomorphism, mitotic figures, vascular permeation, metastasis in its early stage, and poor prognosis.

Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.


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