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・ベキサロテンが奏効したSézary症候群の1例を経験した.
・自験例ではベキサロテンが奏効し,NB-UVB併用にて寛解状態を得られている.
・Sézary症候群は予後不良のため,今後も注意深い経過観察が必要である.
(「症例のポイント」より)
A case of Sézary Syndrome successfully treated with baxarotene
Usui, Toshihiro1)Arai, Satoru1)Shimizu, Hiroki2)Goto, Hiromi3) 1)Department of Dermatology, St. Luke’s International Hospital 2)Department of Hematology, St. Luke’s International Hospital 3)Goto Dermatology Clinic
Bexarotene, a synthesized retinoid X receptor agonist, is a treatment for cutaneous T-cell lymphoma that is newly available in Japan. We describe a 31-year-old woman with Sézary syndrome who was successfully treated with bexarotene and narrow-band UVB therapy. Her disease activity has remained in remission for 14 month with this combination therapy. Although bexarotene induces hypothyroidism and hyperlipidemia, these were well-controlled with oral levothyroxine sodium and pitavastatin.
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