下腿に生じたミノサイクリン塩酸塩による色素沈着

・両側下腿前面に青黒色斑が出現し，ミノサイクリン塩酸塩による色素沈着Ⅱ型と考えられた1例を報告した．

・内服は中止とし，中止後10カ月後に消褪した．

・ミノサイクリンは抗菌作用だけではなく，抗炎症作用があるため，慢性炎症性疾患に対して長期にわたって用いられる薬剤ではあるが，色素沈着については忘れてはならない副作用として広く認識する必要がある．

（「症例のポイント」より）

　

A case of minocycline-induced pigmentation of lower legs

　

Nojiri, Yuka1）Kato, Hiroshi1）Horio, Ai1）Morita, Akimichi1） 1）Department of Dermatology, Nagoya City University School of Medicine

　

A 25-year-old woman visited to our hospital complaining with 10-month history of blue-black pigmentation on her lower legs. She had a history of acne vulgaris and had taken minocycline hydrochloride for 11 months. Clinical feature exhibited blue-black pigmentation on her both lower legs. Histological findings showed brown pigment granules in macrophages clustered around vessels in the reticular dermis, which was positive with the Prussian blue method for iron. Based on these findings, we diagnosed her with minocycline-induced pigmentation. After withdrawal of the minocycline, the pigmentation gradually disappeared. Since minocycline is a medicine that is often used for chronic inflammatory diseases for a long time, pigmentation should be widely recognized as an important side effect.