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Osteoregulation by Physiological Stresses. Regulation of intracellular signal pathways via sensor proteins by oxidative stress. Uehara Takashi 1 1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan. pp.1613-1619
Published Date 2013/10/28
DOI https://doi.org/10.20837/4201311065
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 It has been known that reactive oxygen species(ROS)control the enzymatic and transcriptional activity of proteins via direct modification of cysteine residues. Hence, oxidation of cysteine thiol could be a vital modulator of signal transduction pathways. These findings indicate that some proteins serve as the sensor proteins highly sensitive to ROS. In this review, I show the relationship between intracellular ROS sensor and the regulation of protein function via oxidation.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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