The Roles of Calcium and Phosphorus in Cardiovascular Diseases. Modification of sarco-endoplasmic reticulum Ca2+-ATPase in the failing cardiomyocyte. Ikeda Yasuhiro 1 pp.535-542
Published Date 2013/3/28
DOI https://doi.org/10.20837/4201304077
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 The amplitude and velocity of intracellular Ca2+ cycling determines contractility in normal and failing hearts. Cardiac sarcoplasmic reticulum(SR)is a specialized membranous organelle which determines the property of such intracellular calcium transport in cardiomyocytes. In the SR membrane, sarco-endoplasmic reticulum ATPase(SERCA2a)sequestrates Ca2+ from the cytosol to the SR, thereby regulating cardiac diastolic performance. In the failing hearts, depressed SERCA2a function has been shown to be associated with impaired contractility and aberrant increase in cytosolic Ca2+ concentration. Therefore, molecular targeting of SERCA2a complexes becomes an emerging therapeutic target. In this review, mechanisms modifying SERCA2a function and associated topics is reviewed.


電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社