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 We investigated the efficacy of epinastine hydrochloride ophthalmic solution in Japanese cedar pollen-induced allergic conjunctivitis model and the effects on the Japanese cedar pollen grains rupture.  Epinastine hydrochloride ophthalmic solution significantly reduced the conjunctivitis intensity score and the number of scratching in the Japanese cedar pollen-induced allergic conjunctivitis model. Olopatadine hydrochloride ophthalmic solution significantly reduced the conjunctivitis intensity score and tended to decrease the number of scratching in the model. The Japanese cedar pollen grains rupture and the release of the major allergens from the pollen were increased by drug treatment in a time-dependent manner, and these effects of epinastine hydrochloride ophthalmic solution were lower than those of olopatadine hydrochloride ophthalmic solution.  Our findings indicated that epinastine hydrochloride ophthalmic solution inhibited Japanese cedar pollen-induced allergic conjunctivitis sign and symptom. The major allergens release from the pollen might be involved in the efficacies of epinastine hydrochloride ophthalmic solution in the model.



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電子版ISSN 印刷版ISSN 1344-6932 医薬ジャーナル社

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