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薬剤関連顎骨壊死(medication-related osteonecrosis of the jaw:MRONJ)は,ビスフォスフォネート関連顎骨壊死(bisphosphonate-related osteonecrosis of the jaw:BRONJ)や抗RANKL抗体製剤デノスマブ関連顎骨壊死(denosumab-related osteonecrosis of the jaw:DRONJ),血管新生阻害薬による顎骨壊死を含む総称として米国顎顔面外科学会(American Association of Oral and Maxillofacial Surgeons:AAOMS)が提唱している名称である1)。日本の顎骨壊死検討委員会ポジショニングペーパーでの(血管新生阻害薬を含まない)骨吸収抑制剤関連顎骨壊死(antiresorptive agent-related osteonecrosis of the jaw:ARONJ)に相当する2)。本研究ではARONJ/MRONJのMRI所見の特徴,MRI所見とビスフォスフォネートの投与経路,ビスフォスフォネートの期間,ARONJ/MRONJの臨床病期との関係に関する検討を行う。
Antiresorptive agent-related osteonecrosis of the jaw(ARONJ)has come to be well known complication of antiresorptive medications and medication-related osteonecrosis of the jaw(MRONJ)is a complication of antiresorptive medications and antiangiogenic medications. We investigated the MR features of ARONJ/MRONJ. ARONJ/MRONJ tend to involve posterior portion of the mandible and show high signal intensity on STIR, and low signal intensity on T1-weighted image as seen in active osteomyelitis. MR imaging can assess more accurate extent of perilesional soft tissue inflammation and disease activity than CT or plain radiograph. Clinical symptom of sinusitis help a diagnosis of this disease entity.
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