INTENSIVIST Volume 11, Issue 2 (April 2019)

Overfeeding-induced metabolic adverse effects and their monitoring Hideo TERASHIMA 1,2 1Department of Gastroenterological Surgery University of Tsukuba 2Cancer Center, Ibaraki Seinan Medical Center Hospital pp.327-333
Published Date 2019/4/1
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During the stress response, the energy demand of the body is met by the interaction of endogenous and exogenous energy supplies. The former provides endogenous energy substrates and is physiologically driven as part of the stress response. The latter provides exogenous energy substrates administered through nutrition support therapy. Even during the acute phase of an illness, conventional nutrition support therapy has adopted the basic concept of exogenously providing all of the so-called “energy requirements” which is equated with the predicted or measured resting energy expenditure. However, there is an intrinsic risk that the sum of the endogenous and exogenous energy substrates exceeds the energy demand of the body when increasing the exogenous energy supply without regard for the endogenous energy supply, inevitably leading to adverse effects associated with overfeeding such as hyperglycemia and nutritional stress. From this perspective, this review article presents theory-based explanations on issues surrounding overfeeding and its monitoring.

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11巻2号 (2019年4月)
電子版ISSN 2186-7852 印刷版ISSN 1883-4833 メディカル・サイエンス・インターナショナル