Adverse effects of liberal oxygen therapy Satoshi SUZUKI 1 1Department of Intensive Care, Okayama University Hospital pp.353-363
Published Date 2018/4/1
DOI https://doi.org/10.11477/mf.3102200509
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Oxygen therapy is commonly prescribed for critically ill patients, primarily for the prevention or treatment of hypoxia. Oxygen therapy and subsequent hyperoxemia may also be injurious to lung tissue and other organs. Oxygen toxicity to the lungs includes histopathological changes similar to those seen in acute respiratory distress syndrome, absorption atelectasis, and impaired mucus clearance. Hyperoxemia may also decrease heart rate and cardiac output due to an increase in systemic vascular resistance and vasoconstriction, which may result in decreased organ perfusion, especially to the brain and heart. The effect of oxygen titration by targeting oxygen saturation have been tested in various subgroups of critically ill patients. However, there have been conflicting findings due to heterogeneous patient populations. Future randomized controlled trials should focus on the use of appropriate outcome measures based on patient characteristics.

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